Clinical Articles
Evidence-based guidance on MDR1 drug sensitivity from veterinary toxicologists and emergency medicine specialists. Each article combines clinical protocols with practical advice for protecting vulnerable dogs.
How Ivermectin Kills: The Mechanism Behind MDR1 Toxicity
January 28, 2026Understanding the molecular mechanism that makes ivermectin deadly for MDR1-affected dogs. Why the blood-brain barrier fails and what happens when the drug floods the central nervous system.
Read full articleSafe Heartworm Prevention for Sensitive Breeds
January 25, 2026Not all heartworm preventatives are equal for dogs with MDR1 mutations. A clinical guide to selecting and dosing products that protect without poisoning.
Read full articleClinical Signs of Ivermectin Toxicity: A Veterinarian's Guide
January 22, 2026From subtle ataxia to complete unresponsiveness, recognizing the progression of ivermectin toxicity can save lives. What to watch for and when to act.
Read full articleTreatment Protocol: Managing Ivermectin Overdose
January 19, 2026Step-by-step emergency protocol for ivermectin toxicity, including specific medications, dosages, and supportive care measures that improve survival rates.
Read full articleBeyond Ivermectin: Other Macrocyclic Lactones to Avoid
January 16, 2026Ivermectin gets the headlines, but milbemycin, moxidectin, selamectin, and doramectin all pose risks. A complete guide to the macrocyclic lactone family.
Read full articleMDR1 Mutation Prevalence by Breed: Complete Statistics
January 13, 2026Comprehensive breed-by-breed statistics on MDR1 gene mutation prevalence. Which breeds are most affected by ivermectin sensitivity and what the numbers mean for your dog.
Read full articleHome Safety Guide for MDR1-Affected Dogs
January 10, 2026Practical home safety measures to protect dogs with MDR1 gene mutations from accidental drug exposure. Room-by-room guide to eliminating dangerous substances.
Read full articleUnderstanding the MDR1 Gene Mutation: A Complete Guide
January 7, 2026Comprehensive explanation of the MDR1 gene mutation in dogs, how it causes drug sensitivity, inheritance patterns, and why genetic testing matters.
Read full articleComplete Drug List for MDR1-Affected Dogs: What to Avoid
January 4, 2026Comprehensive list of medications that require caution or avoidance in dogs with MDR1 gene mutations. Includes safe alternatives and risk categories.
Read full articleFirst Aid for Suspected Ivermectin Exposure in Dogs
January 1, 2026Emergency first aid guide for dogs who may have ingested ivermectin or other macrocyclic lactones. What to do immediately and how to prepare for veterinary care.
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